- Additives control
Features and benefits
- Add-on for mass spectrometers
- Direct, real-time analysis of thousands of compounds
- Outstanding operational range: 0.01-2 lpm
- Superb sensitivity: sub-pptv
- Liable for MS/MS or high resolution mass spectrometry
- Fully automated
- Soft ionization method (no damage to the molecule)
- Highest ionization efficiency of the State of the Art due to a patented architecture
SEADM’s LFSESI as Add-On Ion Source for your MS
Virtually all the processes related with the food life cycle have associated a characteristic vapour fingerprint. That allows the research of better food processes as long as those fingerprints can be monitored, analyzed and controlled in real-time.
If you have a mass spectrometer, LFSESI from SEADM allows doing this research, with unmatched efficiency.
With LFSESI (Low Flow Secondary Electrospray Ionizer), you can turn your MS into a powerful vapor analyzer by a fraction of its cost. Its operation is simple: it works as a vapor ion source in substitution of the native source of your MS, and can be seemingly assembled (it weighs only 5-6 kg depending on MS model) in less than 5 minutes.
More than 1,000 different compounds, in real-time, with outstanding sub-ppt sensitivities are at your fingertips!. And just using your pre-existing MS!
Figure 1: LFSESI source coupled to Thermo Fisher Scientific mass spectrometer, including separate control module for easier handling.
Experimental arrangements with LFSESI (Fig. 2) are also very easy to set up and typically include: (a) sample; (b) source of compressed air to drag vapours; (c) the LFSESI Ion Source and its control module, and (d) your favorite MS. Typical samples include food under control conditions, a bioreactor (for fermentation studies, for instance) or even a plant for harvest analysis.
The results are readily available through your MS interface!
Figure 2: Typical experimental arrangements using LFSESI source. Left: volatilome analysis of several varieties of yeast (Scientific Reports, 2017, 7, 14236); right: real-time analysis of plant metabolism (Anal. Chem., 2016, 88 (4), pp 2406–2412)
Our LFSESI has no rival in the field of vapor analysis. Just take a look to the facts (electronic noses are dismissed for insufficient performance):
|System||Mode of operation:||Number of compounds||Limit of detection (LoD)||MS/MS capability||High resolution MS capability||Automated operation|
References: Metabolites 2014, 4, 465-498; Anal. Chem., 2016, 88 (4), pp 2406–2412
Still looking for enhanced sensitivity /selectivity? We can provide a customized IMS (Ion Mobility Spectrometer) for your favorite mass spec using our proprietary technology (Differential Mobility Analysis) to build a complete LFSESI-DMA-MS system. Reference performance is at your fingertips in real-time and fully automated fashion, no chromatographic column needed!
Customer use cases
|Area||Object of the study||Publication (click link to access article)|
|Fermentation and quality||COMPREHENSIVE REAL-TIME ANALYSIS OF THE YEAST VOLATILOME
Scientific Reports, 2017, 7, 14236
|Ripening||RAPID FINGERPRINTING OF GRAPE VOLATILE COMPOSITION USING SECONDARY ELECTROSPRAY IONIZATION ORBITRAP MASS SPECTROMETRY: A PRELIMINARY STUDY OF GRAPE RIPENING
Food Control (2017), 81, 107-112
|Harvest health status||CAPTURING IN VIVO PLANT METABOLISM BY REAL-TIME ANALYSIS OF LOW TO HIGH MOLECULAR WEIGHT VOLATILES|
Anal. Chem, 2016, 88(4), 2406-2412
|Quality grade||PLANAR DIFFERENTIAL MOBILITY ANALYZER WITH A RESOLVING POWER OF 110|
Anal. Chem., 2018, 90 (11), 6735-6741
For more publications on the potential of our LFSESI technology, please check the work of Pablo Martinez-Lozano Sinués: https://www.researchgate.net/profile/Pablo_Sinues