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LFSESI-MS for health applications

For real time, non-invasive analysis of breath and other physiological vapors

LFSESI-MS for health applications image

Applications

  • Breath analysis
  • Illness diagnosis (including pulmonary and cancer)
  • Pathology
  • Pharmacokinetics
  • Metabolism

Features and benefits

  • Direct, real-time analysis
  • Up to 1000 compounds
  • Outstanding operational range: 0.01-2 lpm
  • Sensitivity: sub-pptv
  • Liable for MS/MS or high resolution mass spectrometry
  • Automated
  • Soft ionization method (no damage to the molecule)

The LFSESI is an Add-On Ionizer that turns your MS into a powerful vapor analyzer for health applications

There is growing evidence that physiological processes (either pathogenic or not) have a characteristic vapor fingerprint, which can be assessed either by breath analysis or using culture media. Vapour analysis offers therefore a new universe of possibility for health diagnosis, physiological or pathological studies and pharmacokinetichs.

The new SEADM’s LFSESI (Low Flow Secondary Electrospray Ionizer) allows you to tackle these applications with unprecedented efficiency. Working as a vapor ion source in substitution of the source of your native MS, LFSESI can be seemingly assembled with your current MS (it weighs 5-6 kg depending on MS model) in less than 5 minutes to deliver up to 1000 compounds in real time, with outstanding sub-ppt sensitivities.
lfsesi diagram

Benchmark

Our LFSESI has no rival in the field of vapor analysis. And still at a fraction of the price of a mass spectrometer!

System Mode of operation: Number of compounds Limit of detection (LoD) MS/MS capability High resolution MS capability Automated operation
LFSESI-MS Direct-Real time 100-1000 Sub-pptv YES YES YES
SIFT-MS Direct-Real time ≈100 ppbv NO NO YES
PTR-MS Direct-Real time ≈100 pptv NO NO YES
GC-MS Pre-concentration 100-1000 Sub-pptv YES YES NO

References: Metabolites 2014, 4, 465-498; Anal. Chem., 2016, 88 (4), pp 2406–2412.
For more publications on the potential of our LFSESI technology, please check the work of Pablo Martinez-Lozano Sinués

Application examples

Take a look at some of customer application examples and discover what LFSESI can do to boost your research!

Area Object of the study Samples obtained from: Publication (click link to access article) Ref.

PHYSIOLOGY
Circadian clocks Human breath (3 individuals) Circadian variation of the human metabolome captured by real-time breath analysis Plos One 9 (2014) (12), e114422
Aminoacids in blood Human breath (37) Real-time quantification of amino acids in the exhalome by secondary electrospray ionization-mass spectrometry: A proof-of-principle study Clin. Chem. (2016) 62 (9), 1230–1237

PATHOLOGY
Oral bacteria In vitro bacteria samples Differentiation of oral bacteria in in vitrocultures and human saliva by secondary electrospray ionization – mass spectrometry Sci. Rep.UK 5 (2015) 15163

DISEASE DIAGNOSIS
Pulmonary fibrosis disease Human breath (21) 119 Exhaled breath analysis by real-time mass spectrometry in patients with pulmonary fibrosis Chest (2017) 151 (5), A16
Cancer disease Culture media Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles Sci. Rep-UK (2014), 4, 5196.
Human breath (6) Real-Time Monitoring of Tricarboxylic Acid Metabolites in Exhaled Breath Anal. Chem. (2018) 90 (11), 6453-6460.
Chronic Obstructive Pulmonary Disease Human breath (61) Breath analysis in real time by mass spectrometry in chronic obstructive pulmonary disease Respiration (2014) 87(4)

PHARMACOKYNETICS
Salbutamol effects Human breath (98) Metabolic effects of inhaled salbutamol determined by exhaled breath analysis J. Breath Res. (2017) 11 (4), 046004
Ketamine, propofol, valproic acid Mice breath Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath Angew. Chem. Int. Edit. (2015) 54, 1 – 5

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SEADM S.L. - 2022