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Mobility Front End

Differential Mobility Analyzer Add-on for Mass Spectrometers

Superior sensitivity and selectivity for real-time mass spectrometry at affordable costs

Mobility Front End image

Product Description

A mobility plug-in for mass spectrometers which enables a high speed, pre-filtration stage for liquid and gas samples.

The Mobility Front End has been designed for users of MS in the search of greatest levels of selectivity or in applications where a quantitative measure of analyte cross section is needed.

Advantages and Features

  • High resolution: 100 (peak voltage/FWMH)
  • Lowest limits of detection available (1ppq for TNT)
  • Compelling advantages for the analysis of polymers (specially at moderate and high molecular masses) and bio-molecules (true linear mobility delivered).
  • Reduced sampling time due to higher sensitivity.
  • Accomplishment of measurements in real time (seconds to minutes depending on the application).
  • Complex samples can be thoroughly analyzed (including discovery mode) through a 2D mass-mobility analysis.
  • High versatility: the Front End can be disassembled at any time and leave the MS as a stand alone.
  • Plug in/out to/from your MS in 5 minutes.
  • Robust, highly engineered construction, featuring mirror polishing, micro-slots and full thermal control for the maximum standard of reliability.
  • Full support and maintenance from SEADM.
  • Ion mobility measured as sprayed at atmospheric pressure without any activation.
  • And still at a fraction of the cost of commercial IMS-MS systems!!

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Operational principle of the DMA.

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Example of mobility-mass 2D analysis in a polymer application.

Applications and sectors

Upgrade your MS to tackle more and more challenging applications:

Industry

Medicine And Biology

Environment

Security

Related publications

  • T. Werres, J. Leonhardt, M. Jäger, T. Teutenberg
    “Critical Comparison of Liquid Chromatography Coupled to Mass Spectrometry and Three Different Ion Mobility Spectrometry Systems on Their Separation Capability for Small Isomeric Compounds”
    Chromatographia (2018). https://doi.org/10.1007/s10337-018-3640-z
  • C. Tauber, X. Chen, P. E. Wagner, P. M. Winkler, C. J. Hogan, Jr., A. Maißer
    “Heterogeneous Nucleation onto Monoatomic Ions: Support for the Kelvin-Thomson Theory”
    Chemphyschem. 2018 Sep 20. doi: 10.1002/cphc.201800698
  • A. Maiβer and C. J. Hogan
    “Examination of Organic Vapor Adsorption onto Alkali Metal and Halide Atomic Ions by using Ion Mobility Mass Spectrometry”
    ChemPhysChem, vol. 18, no. 21, pp. 3039–3046. Nov 2017.
  • J. Fernandez de la Mora, R. You and M. R. Zachariah
    Mobility analysis of Inmunoglobulin G ions as-electrosprayed in humid and dry air at atmospheric pressure
    Submitted to J. Phys. Chem, Mar 2017.
  • Fernández de la Mora, J., Amo-González M.
    High Dynamic Range Differential Mobility Analyzer (DMA) Coupled with a Mass Spectrometer and several Ionization Sources
    Submitted to Journal of The American Society for Mass Spectrometry, 2016
  • Derek Oberreit, Vivek Rawat, Carlos Larriba Andaluz, Christopher J. Hogan
    Analysis of heterogeneous water vapor uptake by metal iodide cluster ions via differential mobility analysis-mass spectrometry
    The Journal of Chemical Physics 143(10):104204. Sep 2015
  • Anne Maisser, Jikku Thomas, Carlos Larriba Andaluz, Christopher J. Hogan
    The mass-mobility Distributions of Ions produced by a Po-210 source in air
    Journal of Aerosol Science 90. Aug 2015
  • Fernández de la Mora, J.
    High-Resolution Mobility Analysis of Charge-Reduced Electrosprayed Protein Ions
    Analytical Chemistry, 2015, 87 (7), pp 3729–3735. Mar 2015.
  • Hui Ouyang, Siqin He, Carlos Larriba-Andaluz, and Christopher J. Hogan Jr.
    IMS–MS and IMS–IMS Investigation of the Structure and Stability of Dimethylamine-Sulfuric Acid Nanoclusters
    American Chemical Society. Feb 2015
  • Maißer, V. Premnath, A. Ghosh, T. A. Nguyen, M. Attoui and C. J. Hogan Jr.
    “Determination of gas phase protein ion densities via ion mobility analysis with charge reduction”
    Phys. Chem. Chem. Phys ., 2011, 13, 21630–21641
  • Hogan, Jr., Christopher J., Ruotolo, Brandon T., Robinson, Carol V and Fernandez de la Mora Juan,
    Tandem Differential Mobility Analysis-Mass Spectrometry Reveals Partial Gas-Phase Collapse of the GroEL Complex
    J. Phys. Chem. B 2011, 115, 3614–3621
  • Criado-Hidalgo, E.; Fernández-García, J.; Fernández de la Mora, J.
    Ion Mobility Mass Spectrometry (IMS-MS) Anaysis of Globular Electrosprayed Polymer Ions Obtained via Charge Control
    61st ASMS conference on Mass Spectrometry and Allied Topics; Minneapolis, USA; Jun 2013
  • Hogan Jr. Christopher. J.; Fernandez de la Mora, J.
    Ion Mobility Measurements of Nondenatured 12–150 kDa Proteins and Protein Multimers by Tandem Differential Mobility Analysis–Mass Spectrometry (DMA-MS)
    Journal of the American Society for Mass Spectrometry, 2011
  • Javaheri, H., J.C.Yves Le Blanc, Bruce Thomson, Juan Fernandez de la Mora, Juan Antonio Sillero Sepúlveda , Juan Rus.
    Evaluation of the Analytical Characteristic of a Differential Mobility Analysis coupled to a Triple Quadrupole System (DMA-MSMS)
    Abstracts of the American Association for Mass Spectrometry Conference 2008 (ASMS 08).

Product info

Technical brochure (includes specs)

Related products

  • Low Flow Secondary Electrospray Ionizer

    LFSESI

    Vapor analysis for MS

  • Vapor Analyzer Front End

    Ionic mobility system for your MS

    For advanced Vapor Analysis with Your MS

Technical brochure (includes specs)

  • Front End

Contents

  • Product Description
  • Advantages and Features
  • Applications and sectors
  • Related publications
  • Product info
  • Related products

Read our customer review

J. Kangasluoma

University of Helsinki

(Finland)

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M. A. Ewing et Al.

Indiana University

(U.S.A.)

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