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Ionization sources

For high sensitivity volatile and cluster analysis

SEADM’s engineering team has a long expertise in the development and commercialization of Ion Sources for the most challenging applications:

Low Flow Secondary Electrospray Ionizer

The Low Flow Secondary Electrospray Ionizer (LFSESI) allows converting your mass spec in a powerful vapour analyser at only a fraction of its costs, for multiple applications such as disease diagnosis or pharmacokinetics by breath analysis, study of metabolomics of plants, microbiology, etc.

Learn more

Atmospheric Pressure Photo Ionization

Specifically for non-polar compounds, SEADM is currently developing an Atmospheric Pressure Photo Ionization source, APPI which has already been tested successfully with Furans Dioxins and PAHs and which will be available in the first quarter of year 2017. The source can be used in combination with a DMA or directly coupled to a mass spectrometer.

atmospheric-pressure-ionization-seadm

D-LFSESI

SEADM also offers its latest generation of its electrospray sources for coupling with DMA: the D-nano-ESI and the D-LFSESI , featuring a special desolvation unit and delivering excellent dynamic range results. The D-LFSESI has been optimized for maximum sensitivity for vapour analysis, yielding an unprecedented gain for TNT of 190 counts/fg as part of a D-LFSESI-DMA-MS integrated equipment, which is equivalent to an ionization efficiency of 1 out of 140 neutral molecules.

desolvation-ion-mobility-seadm

Bipolar Electrospray Source

Furthermore, a still experimental Bipolar Electrospray Source, allowing charge reduction for the study of clusters, is now available for the interested researchers.

Read more

bipolar-electrospray-source-seadm

Related publications

LFSESI

  • García-Gómez, D., Martínez-Lozano, P., Barrios-Collado, C., Vidal-de-Miguel, G., Gaugg, M., Zenobi, R.
    Identification of 2-Alkenals, 4-Hydroxy-2-alkenals, and 4-Hydroxy-2,6-alkadienals in exhaled breath condensate by UHPLC-HRMS and in breath by real-time HRMS
    Analytical Chemistry, (2015),  Volume 87, Pages 3087-3093.
  • García-Gómez D., Bregvy L., Barrios-Collado C., Vidal de Miguel G., Zenobi R.,
    Real-Time High-Resolution Tandem Mass Spectrometry Identifies Furan Derivatives in Exhaled Breath
    Analytical Chemistry, (2015), 87 (13), pp 6919–6924.
  • Vidal de Miguel, G.
    Add-on Secondary Electrospray Ionizer for pre-existing MS and for high sensitivity volatile analysis
    Analytix Conference, Jun-2015.

APPI

  • Evaluating a Rapid Atmospheric Pressure Photoionization – Mass Spectrometry (APPI-MS) Method for the Detection of Polychlorinated Dibenzodioxins (PCDD) and Furans (PCDF) in Real Environmental Samples Collected within the Vicinity of Industrial Incinerators
    36th International Symposium on Halogenated Persistent Organic Pollutants (Dioxin 2016)
  • McCulloch, R.; Amo-González, M.
    Fast detection of environmental vapors by thermal desorption – atmospheric pressure photoionization differential mobility analysis – mass spectrometry (TD-APPI-DMA-MS)
    64th ASMS Conference on Mass Spectrometry and Allied Topics; San Antonio, Texas, Jun 2016
  • Gómez M.; Amo, M.; Cuesta R.; Del Castillo J.C.; Mc Culloch R.; Martín J.M.
    Tracking Polychlorinated Dibenzodioxin (PCDD) and Furan (PCDF) concentrations within the environment surrounding incineration facilities using Atmospheric Pressure Photoionization-Mass Spectrometry (APPI-MS)
    CEM 12th International Conference and exhibition on Emissions monitoring, May 2016

Desolvating electrospray sources for coupling with the DMA

  • Fernandez de la Mora J., Amo M.
    High Dynamic Range Differential Mobility Analyzer (DMA) Coupled with a Mass Spectrometer and several Ionization Sources
    Submitted to Journal of The American Society for Mass Spectrometry, 2016
  • Amo, M.; Alvaro, A.; McCulloch, R. Fernández de la Mora, J.
    Development of a high dynamic range differential mobility analyzer (DMA) coupled with a mass spectrometer and nano-ESI source
    63rd ASMS Conference on Mass Spectrometry and Allied Topics; Missouri, USA; Jun 2015
  • Fernández de la Mora, G., Zamora D., Amo-González M., Fernández de la Mora J.
    Detecting explosive vapours in large volume freight: 2016 improvements
    Workshop on Spectrometry for security applications, Birmingham. Dec, 2016

Bipolar Electrospray source

  • G. Steiner, M. Orzan, I. Nagler, E. Petrakakis, M. Selimovic, C. Tauber, F. Tettich
    Improving airborne nanoparticle and cluster detection with the butanol based laminar flow condensation nuclei counters Grimm 5.403 and 5.412
    Aerosol Technology, 2018, Bilbao (Spain)
  • Fernandez de la Mora J. Barrios-Collado C.
    A Bipolar electrospray source of singly charged salt clusters of precisely controlled composition
    Submitted to Aerosol Science and Technology, 2017, 51, 6, 778–786

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SEADM S.L. - 2022